Overall Record: 10-10-0 League Records: 5-5-0
| Date | Time | Level | Opponent/Title | Game Type | Result | Facility |
| 02-16-2022 | 04:00PM | Varsity | TBA | Scrimmage | Mater Dei Pool | |
| 02-16-2022 | 04:00PM | Frosh/Soph | TBA | Scrimmage | Mater Dei Pool | |
| 02-16-2022 | 04:00PM | Junior Varsity | TBA | Scrimmage | Mater Dei Pool | |
| 02-22-2022 | 03:15PM | Varsity | University | Non-League | W (97-73) | Mater Dei Pool |
| 02-22-2022 | 03:15PM | Frosh/Soph | University | Non-League | Mater Dei Pool | |
| 02-22-2022 | 03:15PM | Junior Varsity | University | Non-League | Mater Dei Pool | |
| 02-26-2022 | 01:00PM | Varsity | @ Woodbridge | Non-League | L (76-94) | Orange Coast College |
| 02-26-2022 | 01:00PM | Frosh/Soph | @ Woodbridge | Non-League | Orange Coast College | |
| 02-26-2022 | 01:00PM | Junior Varsity | @ Woodbridge | Non-League | Orange Coast College | |
| 02-26-2022 | 01:00PM | Varsity | @ Huntington Beach | Non-League | W (118-52) | Orange Coast College |
| 02-26-2022 | 01:00PM | Junior Varsity | @ Huntington Beach | Non-League | Orange Coast College | |
| 02-26-2022 | 01:00PM | Frosh/Soph | @ Huntington Beach | Non-League | Orange Coast College | |
| 03-03-2022 | 03:00PM | Varsity | @ TBA - Capo Valley Relays Girls | League | Capistrano Valley | |
| 03-03-2022 | 03:00PM | Frosh/Soph | @ TBA - Capo Valley Relays Prelim | League | Capistrano Valley | |
| 03-05-2022 | 08:00AM | Varsity | @ TBA - Capo Valley Relays Finals | League | Capistrano Valley | |
| 03-05-2022 | 08:00AM | Frosh/Soph | @ TBA - Capo Valley Relays Finals | League | Capistrano Valley | |
| 03-15-2022 | 03:15PM | Varsity | Los Alamitos | Non-League | L (35-135) | Mater Dei Pool |
| 03-15-2022 | 03:15PM | Frosh/Soph | Los Alamitos | Non-League | L (55-98) | Mater Dei Pool |
| 03-15-2022 | 03:15PM | Junior Varsity | Los Alamitos | Non-League | L (49-121) | Mater Dei Pool |
| 03-18-2022 | 09:00AM | Varsity | @ TBA - Mission Viejo Diving Invi | Non-League | Marguerite Aquatic Center | |
| 03-22-2022 | 03:15PM | Varsity | @ Tesoro | Non-League | L (58-112) | Tesoro |
| 03-22-2022 | 03:15PM | Frosh/Soph | @ Tesoro | Non-League | W (94-59) | Tesoro |
| 03-22-2022 | 03:15PM | Junior Varsity | @ Tesoro | Non-League | W (129-41) | Tesoro |
| 03-24-2022 | 03:15PM | Varsity | @ Lutheran/Orange | League | W (124-43) | Santiago Canyon College |
| 03-24-2022 | 03:15PM | Frosh/Soph | @ Lutheran/Orange | Non-League | Santiago Canyon College | |
| 03-24-2022 | 03:15PM | Junior Varsity | @ Lutheran/Orange | Non-League | W (146-4) | Santiago Canyon College |
| 03-25-2022 | TBA | Frosh/Soph | @ TBA - OC F/S Invite Prelims | Tournament | Brea Olinda | |
| 03-26-2022 | 09:00AM | Frosh/Soph | @ TBA - OC F/S Invite Finals | Tournament | Brea Olinda | |
| 03-31-2022 | 03:15PM | Varsity | Santa Margarita | League | L (24-136) | Mater Dei Pool |
| 03-31-2022 | 03:15PM | Frosh/Soph | Santa Margarita | League | L (30-124) | Mater Dei Pool |
| 03-31-2022 | 03:15PM | Junior Varsity | Santa Margarita | League | L (36-134) | Mater Dei Pool |
| 04-02-2022 | 10:00AM | Varsity | @ TBA - Santa Margarita Diving In | Non-League | Santa Margarita | |
| 04-07-2022 | 03:15PM | Varsity | Rosary Academy | League | W (135-26) | Mater Dei Pool |
| 04-07-2022 | 03:15PM | Frosh/Soph | Rosary Academy | League | W (111-35) | Mater Dei Pool |
| 04-07-2022 | 03:15PM | Junior Varsity | Rosary Academy | League | W (127-0) | Mater Dei Pool |
| 04-13-2022 | 03:15PM | Varsity | JSerra Catholic | League | L (67-103) | Mater Dei Pool |
| 04-13-2022 | 03:15PM | Frosh/Soph | JSerra Catholic | League | L (55-97) | Mater Dei Pool |
| 04-13-2022 | 03:15PM | Junior Varsity | JSerra Catholic | League | W (120-2) | Mater Dei Pool |
| 04-23-2022 | 10:00AM | Varsity | @ TBA - Catholic Invite | Tournament | Santa Margarita | |
| 04-25-2022 | 08:00AM | Varsity | @ TBA - Trinity League Coed Divin | League | Marguerite Aquatic Center | |
| 04-26-2022 | 04:00PM | Varsity | @ TBA - Trinity League Girls Prel | League | Santa Margarita | |
| 04-26-2022 | 04:15PM | Junior Varsity | @ TBA - Trinity League Girls Prel | League | Santa Margarita | |
| 04-26-2022 | 04:15PM | Frosh/Soph | @ TBA - Trinity League Girls Prel | League | Santa Margarita | |
| 04-27-2022 | 08:30AM | Varsity | @ TBA - CIFSS Diving | Playoffs | Marguerite Aquatic Center | |
| 04-29-2022 | 02:00PM | Varsity | @ TBA - Trinity League Coed Final | League | Santa Margarita | |
| 04-29-2022 | 02:00PM | Junior Varsity | @ TBA - Trinity League Coed Final | League | Santa Margarita | |
| 04-29-2022 | 02:00PM | Frosh/Soph | @ TBA - Trinity League Coed Final | League | Santa Margarita | |
| 05-04-2022 | 09:00AM | Varsity | TBA - CIF Prelims | Playoffs | Marguerite Aquatic Center | |
| 05-06-2022 | 03:00PM | Varsity | @ TBA - CIF Finals | Playoffs | Marguerite Aquatic Center | |
| 05-12-2022 | 02:30PM | Varsity | TBA - CIF State Prelims | Playoffs | Clovis West | |
| 05-14-2022 | 02:30PM | Varsity | TBA - CIF State Finals | Playoffs | Clovis West |