Overall Record: 8-13-1 League Records: 5-6-1
| Date | Time | Level | Opponent/Title | Game Type | Result | Facility |
| 02-16-2022 | 04:00PM | Varsity | TBA - MD Intersquad Meet | Scrimmage | Mater Dei Pool | |
| 02-16-2022 | 04:00PM | Frosh/Soph | TBA | Scrimmage | Mater Dei Pool | |
| 02-16-2022 | 04:00PM | Junior Varsity | TBA - MD Intersquad Meet | Scrimmage | Mater Dei Pool | |
| 02-22-2022 | 03:15PM | Varsity | University | Non-League | W (91-70) | Mater Dei Pool |
| 02-22-2022 | 03:15PM | Frosh/Soph | University | Non-League | Mater Dei Pool | |
| 02-22-2022 | 03:15PM | Junior Varsity | University | Non-League | Mater Dei Pool | |
| 02-26-2022 | 03:15PM | Varsity | @ Woodbridge | Non-League | L (63-106) | Orange Coast College |
| 02-26-2022 | 03:15PM | Frosh/Soph | @ Woodbridge | Non-League | Orange Coast College | |
| 02-26-2022 | 03:15PM | Varsity | @ Huntington Beach | Non-League | L (45-125) | Orange Coast College |
| 02-26-2022 | 03:15PM | Junior Varsity | @ Woodbridge | Non-League | Orange Coast College | |
| 02-26-2022 | 03:15PM | Junior Varsity | @ Huntington Beach | Non-League | Orange Coast College | |
| 02-26-2022 | 03:15PM | Frosh/Soph | @ Huntington Beach | Non-League | Orange Coast College | |
| 03-04-2022 | 03:00PM | Varsity | @ TBA - Capo Valley Relays Boys | League | Capistrano Valley | |
| 03-04-2022 | 03:00PM | Frosh/Soph | @ TBA - Capo Valley Relays Boys | League | Capistrano Valley | |
| 03-05-2022 | 08:00AM | Varsity | @ TBA - Capo Valley Relays Finals | League | Capistrano Valley | |
| 03-05-2022 | 08:00AM | Frosh/Soph | @ TBA - Capo Valley Relays Finals | League | Capistrano Valley | |
| 03-15-2022 | 03:15PM | Varsity | Los Alamitos | Non-League | L (73.5-96.5) | Mater Dei Pool |
| 03-15-2022 | 03:15PM | Frosh/Soph | Los Alamitos | Non-League | L (54-100) | Mater Dei Pool |
| 03-15-2022 | 03:15PM | Junior Varsity | Los Alamitos | Non-League | W (87-83) | Mater Dei Pool |
| 03-16-2022 | 03:15PM | Varsity | @ St. John Bosco | League | W (109-51) | St. John Bosco |
| 03-16-2022 | 03:15PM | Frosh/Soph | @ St. John Bosco | League | St. John Bosco | |
| 03-16-2022 | 03:15PM | Junior Varsity | @ St. John Bosco | League | W (130-37) | St. John Bosco |
| 03-22-2022 | 03:15PM | Varsity | @ Tesoro | Non-League | L (73-97) | Tesoro |
| 03-22-2022 | 03:15PM | Frosh/Soph | @ Tesoro | Non-League | L (59-92) | Tesoro |
| 03-22-2022 | 03:15PM | Junior Varsity | @ Tesoro | Non-League | L (82-88) | Tesoro |
| 03-24-2022 | 03:15PM | Varsity | @ Lutheran/Orange | League | W (104-65) | Santiago Canyon College |
| 03-24-2022 | 03:15PM | Frosh/Soph | @ Lutheran/Orange | Non-League | Santiago Canyon College | |
| 03-24-2022 | 03:15PM | Junior Varsity | @ Lutheran/Orange | Non-League | W (133-20) | Santiago Canyon College |
| 03-25-2022 | TBA | Frosh/Soph | @ TBA - OC F/S Invite Prelims | Tournament | Brea Olinda | |
| 03-26-2022 | 09:00AM | Frosh/Soph | @ TBA - OC F/S Invite Finals | Tournament | Brea Olinda | |
| 03-31-2022 | 03:15PM | Varsity | Santa Margarita | League | L (54-115) | Mater Dei Pool |
| 03-31-2022 | 03:15PM | Frosh/Soph | Santa Margarita | League | L (40-114) | Mater Dei Pool |
| 03-31-2022 | 03:15PM | Junior Varsity | Santa Margarita | League | L (68-112) | Mater Dei Pool |
| 04-07-2022 | 03:15PM | Varsity | Servite | League | T (85-85) | Mater Dei Pool |
| 04-07-2022 | 03:15PM | Frosh/Soph | Servite | League | L (66-79) | Mater Dei Pool |
| 04-07-2022 | 03:15PM | Junior Varsity | Servite | League | W (108-61) | Mater Dei Pool |
| 04-13-2022 | 03:15PM | Frosh/Soph | JSerra Catholic | League | L (57-88) | Mater Dei Pool |
| 04-13-2022 | 03:15PM | Varsity | JSerra Catholic | League | L (82-88) | Mater Dei Pool |
| 04-13-2022 | 03:15PM | Junior Varsity | JSerra Catholic | League | W (121-0) | Mater Dei Pool |
| 04-23-2022 | 10:00AM | Varsity | @ TBA - Catholic Invite | Tournament | Santa Margarita | |
| 04-27-2022 | 04:00PM | Varsity | @ TBA - Trinity League Boys Preli | League | Santa Margarita | |
| 04-27-2022 | 03:00PM | Frosh/Soph | @ TBA - Trinity League Boys Preli | League | Santa Margarita | |
| 04-27-2022 | 03:00PM | Junior Varsity | @ TBA - Trinity League Boys Preli | League | Santa Margarita | |
| 04-29-2022 | 02:00PM | Varsity | @ TBA - Trinity League Finals | League | Santa Margarita | |
| 04-29-2022 | 03:00PM | Frosh/Soph | @ TBA - Trinity League Finals | League | Santa Margarita | |
| 04-29-2022 | 03:00PM | Junior Varsity | @ TBA - Trinity League Finals | League | Santa Margarita | |
| 05-04-2022 | 09:00AM | Varsity | TBA - CIF Prelims | Playoffs | Marguerite Aquatic Center | |
| 05-06-2022 | 03:00PM | Varsity | @ TBA - CIF Finals | Playoffs | Marguerite Aquatic Center | |
| 05-13-2022 | 02:30PM | Varsity | TBA - CIF State Prelims | Playoffs | Clovis West | |
| 05-14-2022 | 02:30PM | Varsity | TBA - CIF State Finals | Playoffs | Clovis West |